1. University Research

Circulating Ionized Magnesium as a Measure of Supplement Bioavailability: Results from a
Pilot Study for Randomized Clinical Trial
Zhan, J.; Wallace, T.C.; Butts, S.J.; Cao, S.; Ansu, V.; Spence, L.A.; Weaver, C.M.; Gletsu-
Miller, N. Nutrients 2020, 12, 1245.

2. RnA ReSet® With GrassrootsHealth


Welcome to this special project, offered by RnA ReSet® and GrassrootsHealth!   

GrassrootsHealth Nutrient Research Institute is the World’s Largest Crowd-Funded Nutrient Research Project, Following the Guidelines Developed by Their Former Director of Research, Dr. Robert P. Heaney. Science Based Information From 1000’s of Participants That You Can Use for Your Own Health.


The National Academy of Sciences has determined that when it comes to magnesium intake, most American men obtain only about 80 percent of the recommended daily allowance (RDA), and women average only 70 percent.[1]   This means both men and women don’t even get this minimal amount of magnesium. Most magnesium experts agree that the current RDA is inadequate to prevent magnesium deficiency.

The current Fact Sheet on Magnesium for Health Professionals on an NIH website confirms that the problem of magnesium-deficient diets continues.[1] The NIH says “Magnesium dietary surveys of people in the United States consistently show that intakes of magnesium are lower than recommended amounts.” An analysis of data from the National Health and Nutrition Examination Survey (NHANES) of 2005–2006 found that a majority of Americans of all ages ingest less magnesium from food than their respective Estimated Average Requirements (EAR).

The result of widespread magnesium deficiency may be contributing to the rise in many health problems such as:

  • Atrial fibrillation
  • Stroke
  • Heart failure
  • Preeclampsia
  • Bone health
  • Mental, emotional & behavioral disorders
  • Diabetes
  • Thyroid imbalance
  • Musculoskeletal pain

Here are some common questions about magnesium that will be addressed with participation in this Magnesium*PLUS Focus Project:

  • How might magnesium be working for me?
  • What specific health outcomes are associated with this nutrient for me, for the total group?
  • How can I figure out how much to take? What’s the dose-response relationship for all? For me?
  • Does it matter if I’m also taking vitamin D? Omega-3?
  • Does it matter what compound of this nutrient I take? What product? What time of day? How often?
  • Does taking magnesium affect my level of thyroid stimulating hormone (TSH) and subsequent thyroid function?
  • What are the demonstrated health outcomes used to create this nutrient’s recommended range?

Magnesium is Essential to Thyroid Health

Magnesium is a key nutrient in thyroid function and for the production of thyroid hormones.  Studies have shown that magnesium may lower thyroid stimulating hormone and improve thyroid function. They have also linked low levels of magnesium to hyperthyroidism. Eight other minerals are associated with thyroid hormone production as cofactors in metabolic pathways. Of these eight, zinc, selenium, and copper deficiency can block thyroid hormone receptors and lead to thyroid imbalance. These minerals may also be measured by adding the PLUS Elements test (which also includes toxic minerals lead, cadmium and mercury).

This special project offered by Dr. Carolyn Dean includes an added focus on thyroid health with the addition of the TSH blood spot test.  By adding TSH, participants can get a better idea of how their nutrient status may be affecting their thyroid health, and subsequently, the many symptoms associated with thyroid imbalance. TSH elevation reflects the need for more thyroid hormone production, which can e accomplished by providing the thyroid with the minerals that occur in ReMyte.

By participating in this project, you will learn your individual response to supplementation via blood testing and analysis of a detailed questionnaire and monthly tracking of your symptoms. 

Everyone experiences a unique response to supplementation or nutrient intake called the dose-response, which can be due to factors such as current health conditions, digestive health, co-nutrient status, medications, genetics and more. The vitamin D dose-response chart below illustrates the wide variation in response for individuals at a specific intake amount. For example, among those taking 5000 IU/day of vitamin D, resulting serum levels ranged from about 20 to 140 ng/ml (optimum is 40-60 ng/ml). Similar variations are seen with omega-3 and magnesium intake, and other nutrients. With this testing, you can learn your individual dose response.

Measuring your nutrient status quarterly, as well as completing monthly assessments and then re-testing is the only way to tell if your nutrient intake is helping you achieve sufficient or desired nutrient status which is tied to particular health outcomes. 

GrassrootsHealth researchers will analyze the collected data and publish scientific papers on key results when sample size reaches 1000 participants. There will be preliminary analyses and interim newsletters available for all during the enrollment phase.

Join the Magnesium*PLUS Focus Project today! Knowing your levels is key to managing your own health.


1 Institute of Medicine, Dietary Reference Intake for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride, National Academies Press, Washington, DC, 1997.



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